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In addition, it is thought that the mechanisms that ensure PQC in the nucleus are distinct from those of other organelles [108, 109], an example being the exclusive use of K48-linked ubiquitin chains required for proteasomal degradation of misfolded proteins, and thus independency of K11-specific ligases and chaperones [110]

Zhai et al

To help your body adjust, drink plenty of water and avoid strenuous activity for a few hours after the injection if you feel sensitive

However, it is clear that GSIS can also occur independently of K ATP channel activity and this is known as the K ATP -independent GSIS